https://www.delphistem.com/hello daily 1.0 2025-05-21 https://www.delphistem.com/values daily 0.75 2025-05-20 https://www.delphistem.com/contact daily 0.75 2025-05-21 https://www.delphistem.com/team daily 0.75 2026-05-12 https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/00c57508-c8d5-4f42-a6d0-d3c2f1474099/undefined-high.gif Team Danae Moya, MBA, delphistem COO & Co-Founder Dr. Noel Moya, PhD, delphistem CEO & Co-Founder https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/410dc04a-a6b2-4392-97e1-c111a7bcfe54/IMG_4776.jpg Team Danae Moya, MBA, delphistem COO & Co-Founder presenting to delphistem team https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/b18bb96d-73d1-46d7-b1e7-88540a9a9011/IMG_4716.jpg Team Dr. Noel Moya, PhD, delphistem CEO & Co-Founder presenting to delphistem team https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/acc6dd7d-f4f6-4583-bc93-76e909bc2b31/IMG_4603.jpg Team Dr. Noel Moya, PhD, delphistem CEO & Co-Founder and team https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/76cebcbe-d192-4fe1-b3e9-f763f5655f8b/IMG_4497.jpg Team https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/8e23b250-b817-4f02-8f87-3f69ca31cde5/IMG_4735.jpg Team https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/6fcc3d1c-6f73-4c0f-ae59-9cadda0a68a6/IMG_6545.jpeg Team https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/a6404280-178c-41de-aaf4-cda6eee9c978/IMG_4521.jpg Team https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/fc91f0a7-cba6-4e38-a613-5194b07c0ddc/IMG_4733.jpg Team https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/76d82208-eef5-4fd7-a28b-9b547d891230/IMG_4504.jpg Team https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1bc0605e-7b28-4f6c-823e-6b9226454601/IMG_4529.jpg Team https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/cb3bd898-6473-4d80-a2c7-1d6fca9626bc/IMG_4566.jpg Team Dr. Noel Moya, PhD, delphistem CEO & Co-Founder https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1685461082668-A6GZ5ADH437QQJZNEMUN/IMG_4767.jpg Team Danae Moya, MBA, delphistem COO & Co-Founder https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/60731cdf-042f-4cbd-9db1-5c14aa041d9a/IMG_4559.jpg Team Dr. Noel Moya, PhD, delphistem CEO & Co-Founder https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/3947b7d1-68f1-4acc-812e-49ec5a0e6f46/IMG_3134.jpg Team Danae Moya, MBA, delphistem COO & Co-Founder Dr. Noel Moya, PhD, delphistem CEO & Co-Founder https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/43c1f4f0-c9c1-4e70-be65-1ed736fb21af/IMG_9673.jpg Team Dr Noel Moya, PhD delphistem CEO & Co-Founder https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1f83c08b-3f35-4c54-bb60-bf233534eb29/IMG_4695.jpg Team https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/acfb1f8c-c7d2-4bfc-944f-74bf6278aa8f/IMG_0073.jpg Team Dr Noel Moya, PhD delphistem CEO & Co-Founder https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/74c6298e-549a-4ea1-b7ca-8dbb8107816f/IMG_6465.jpg Team Danae Moya, delphistem Co-Founder & COO https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/2e7ddb28-e7bc-47ce-be63-e8e45ab3a1a8/IMG_9501.JPG Team Danae Moya, MBA delphistem COO & Co-Founder Dr. Noel Moya, PhD delphistem CEO & Co-Founder https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/a6e1ea2c-1afc-4cb1-a7aa-9b616c49560a/IMG_6775.jpg Team Dr. Noel Moya, PhD, delphistem CEO & Co-Founder https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/e2680748-062d-4cb7-ac88-13ff11d29e7e/IMG_0170+2.JPG Team Danae Moya, MBA, delphistem COO & Co-Founder Dr. Noel Moya, PhD, delphistem CEO & Co-Founder https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/2ddd1212-773d-4981-b029-6b9cb3500a91/IMG_6577.jpeg Team https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1c6cabda-449d-4235-8cb8-720a2dfb5409/IMG_6748.jpg Team delphistem lab https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/2b988dd9-4026-4a79-ad1b-509d3833c592/IMG_6479+2.jpeg Team https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/9650e8c7-d4ea-4edc-9a7e-fced235ad7ab/IMG_6490.jpeg Team Dr. Noel Moya, PhD, delphistem CEO & Co-Founder https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/71c0a2fc-c5fd-48de-9d7d-f33c8059748a/IMG_6457+2.jpeg Team https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/0fe2ec73-cde5-41c3-86b7-cf5840f13d81/IMG_6681.jpg Team https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/d03281f7-736e-4a01-b9cc-5e559ac2492f/IMG_6898.jpg Team Danae Moya, MBA, delphistem COO & Co-Founder Dr. Noel Moya, PhD, delphistem CEO & Co-Founder https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/b87e8f59-55d9-486d-bf99-1f53ea64c82d/IMG_6575+2+2.jpeg Team https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/925b3b08-9aa7-4b7d-82aa-fd9dcee95ed9/IMG_6479.jpeg Team https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/762d19a1-cf14-4542-b98b-a9a8f9a372c7/IMG_6778.jpg Team Danae Moya, MBA, delphistem COO & Co-Founder Dr. Noel Moya, PhD, delphistem CEO & Co-Founder https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/6c0d0094-648a-4743-bdf3-c57cbe26dd59/IMG_8366.JPG Team Dr. Noel Moya, PhD, delphistem CEO & Co-Founder https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/066a08f6-35eb-46c3-84a1-3d9dc292e165/IMG_4111.png Team - Dr. Noel Moya, PhD Co-founder & Chief Science Officer Tobias Keene, D.D.S. Hailing from Richmond, Virginia, Dr. Tobias Keene brings a bit of unabashed Southern hospitality to all his patients. He moved to Washington, D.C. over thirty years ago as a freshman at Ivy College. Right after graduation, he attended World University’s School of Dentistry. Before opening Keene Dental in 1994, he worked for free clinics and some of the finest practices in the District. He is part of the 123 Dental Association and stays up-to-date on the latest dental discoveries. When not striving to keep his patients happy and healthy, he’s enjoys hiking with his family in Rock Creek Park. https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/89f06638-52be-4aa3-958f-2987108a15f0/003-l7mN-sUFjVw.jpeg Team - Make it stand out Jeff Searles Chief Executive Officer Jeff Searles is an entrepreneur and operator with over two decades of experience building and scaling companies across biotech, fintech, and insurtech. He has worked across product, partnerships, and go-to-market in complex, regulated environments, helping early-stage companies grow into scaled platforms. He previously served as CEO of VARDA and COO of Aural Analytics, a biotech company focused on early detection of neurodegenerative disease. Jeff leads company strategy, fundraising, and execution. https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/094990f5-4e37-4ba5-a1d1-dd5caee26a18/IMG_6931.jpg Team - Danae [Vassilopoulou] Moya, MBA Co-founder & Chief Operations Officer Danae Moya brings global experience across strategy, operations, and growth. She began her career in international media and marketing, developing global strategy across London and Dubai. She later earned her Executive MBA from London Business School, with additional work at Columbia Business School and IAE Business School. Her background includes leadership roles in luxury consumer businesses, with a focus on scaling operations and building high-performing teams. After a personal connection to the impact of serious illness, she co-founded delphistem to help bring advanced medical innovation to broader patient populations. Danae leads operations, partnerships, and go-to-market execution. https://www.delphistem.com/scientific-publications daily 0.75 2024-02-19 https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1630583420076-9BRV2Z8CGWDZC5AYCP7C/IMG_1599.jpg Scientific Publications - Increasing Gene Editing Efficiency for CRISPR-Cas9 by Small RNAs in Pluripotent Stem Cells CRISPR Journal Volume 4, No. 4 August 2021, Gene manipulations of human induced pluripotent stem cells (iPSCs) by CRISPR-Cas9 genome engineering are widely used for disease modeling and regenerative medicine applications. There are two competing pathways, non-homologous end joining (NHEJ) and homology directed repair (HDR) that correct the double-strand break generated by CRISPR-Cas9. Here, we improved gene editing efficiency of gene knock-in (KI) in iPSCs with minimum components by manipulating the Cas9 expression vector. Either we inserted short hairpin RNA expression cassettes to downregulate DNAPK and XRCC4, two main players of the NHEJ pathway, or we increased cell survival by inserting an anti-apoptotic expression cassette of miRNA-21 into the Cas9 vector. For an easy readout, the pluripotency gene SOX2 was targeted with a T2A-tdTomato reporter construct. In vitrodownregulating DNAPK and XRCC4 increased the targeting efficiency of SOX2 KI by around twofold. Furthermore, co-expression of miRNA-21 and Cas9 improved the efficiency of SOX2 KI by around threefold. Altogether, our strategies provide a simple and valuable approach for efficient CRISPR-Cas9 gene editing in iPSCs. https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1630582683494-538HGXE4OBI2N8EU8QD5/IMG_1597.jpg Scientific Publications - Generation of a human iPSC line harboring a biallelic large deletion at the INK4 locus (HMGUi001-A-5) Stem Cell Research, Volume 47, August 2020, 101927 The INK4 locus is considered as a hot-spot region for the complex genetic disorders, including cancer, type 2 diabetes (T2D) and coronary artery disease (CAD). By CRISPR/Cas9 gene editing, we generated a human induced pluripotent stem cell (hiPSC) line (HMGUi001-A-5) deleting an 8 kb genomic DNA encompassing six T2D-associated SNPs at the INK4 locus. The resulting hiPSC line revealed a normal karyotype, preserved pluripotency and was able to differentiate towards germ layers, endoderm, mesoderm and ectoderm. Thus, the HMGUi001-A-5 line could provide a valuable cellular model to explore the molecular mechanisms linking these SNPs to T2D and other genetic disorders. https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1630582735280-S903FXT0T1A25PHR9UAW/IMG_1596.jpg Scientific Publications - Generation of a homozygous ARX nuclear CFP (ARXnCFP/nCFP) reporter human iPSC line (HMGUi001-A-4) Stem Cell Research Volume 46, July 2020, 101874 The aristaless related homeobox (ARX) transcription factor plays a crucial role in glucagon-producing α-cell differentiation. Here, we generate an ARX reporter iPSC line by 3′ fusion of an intervening viral T2A sequence followed by a nuclear-localized histone 2B-cyan fluorescent protein (nCFP). The resulting cells have a normal karyotype and preserved pluripotency. In vitro differentiation of the ARXnCFP/nCFP reporter iPSCs towards the endocrine lineage confirmed the specific co-expression of the reporter protein in human glucagon+ α-like cells. Thus, ARXnCFP/nCFP iPSC line will provide a powerful tool to monitor human α-cell progenitor differentiation as well as ARX+ α-like cell function in vitro. https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1630582790610-RTFEV37YNDO3SBH58TM2/IMG_1598.jpg Scientific Publications - Endogenous WNT Signaling Regulates hPSC-Derived Neural Progenitor Cell Heterogeneity and Specifies Their Regional Identity Stem Cell Reports, Volume 3, Issue 6, 9 December 2014, Pages 1015-1028 Neural progenitor cells (NPCs) derived from human pluripotent stem cells (hPSCs) are a multipotent cell population that is capable of nearly indefinite expansion and subsequent differentiation into the various neuronal and supporting cell types that comprise the CNS. However, current protocols for differentiating NPCs toward neuronal lineages result in a mixture of neurons from various regions of the CNS. In this study, we determined that endogenous WNT signaling is a primary contributor to the heterogeneity observed in NPC cultures and neuronal differentiation. Furthermore, exogenous manipulation of WNT signaling during neural differentiation, through either activation or inhibition, reduces this heterogeneity in NPC cultures, thereby promoting the formation of regionally homogeneous NPC and neuronal cultures. The ability to manipulate WNT signaling to generate regionally specific NPCs and neurons will be useful for studying human neural development and will greatly enhance the translational potential of hPSCs for neural-related therapies. https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1630582850139-O1XFAP7OXVTNWQQ45G75/IMG_1594.jpg Scientific Publications - Analysis of SOX2-expressing cell populations derived from human pluripotent stem cells Stem Cell Reports . 2013 Oct 31; 1(5): 464-78 SOX2 is involved in several cell and developmental processes, including maintenance of embryonic stem cells, differentiation of neural progenitor cells, and patterning of gut endoderm. To study its role in a human system, we generated a human embryonic stem cell (hESC) line harboring a reporter gene encoding GFP in the SOX2 locus. This SOX2 reporter line faithfully recapitulates expression of the SOX2 gene in undifferentiated human pluripotent stem cells (hPSCs), neural progenitor cells (NPCs), and anterior foregut endoderm (AFE). In undifferentiated hESCs, GFP expression corresponds to those cells with highest levels of expression of genes associated with the pluripotent state. In NPCs, expression of GFP can be employed to isolate cells expressing markers associated with NPC multipotency. In AFE, we used transcriptome-wide expression analysis to identify cell surface markers with elevated expression in this population, thereby facilitating isolation and purification of this hPSC-derived cell population. https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1630582901050-6HPH0N0V2G44LBCCPMIO/IMG_1593.jpg Scientific Publications - A Hormone-Dependent Module Regulating Energy Balance Cell, VOLUME 145, ISSUE 4, P596-606, MAY 13, 2011 Under fasting conditions, metazoans maintain energy balance by shifting from glucose to fat burning. In the fasted state, SIRT1 promotes catabolic gene expression by deacetylating the forkhead factor FOXO in response to stress and nutrient deprivation. The mechanisms by which hormonal signals regulate FOXO deacetylation remain unclear, however. We identified a hormone-dependent module, consisting of the Ser/Thr kinase SIK3 and the class IIa deacetylase HDAC4, which regulates FOXO activity in Drosophila. During feeding, HDAC4 is phosphorylated and sequestered in the cytoplasm by SIK3, whose activity is upregulated in response to insulin. SIK3 is inactivated during fasting, leading to the dephosphorylation and nuclear translocation of HDAC4 and to FOXO deacetylation. SIK3 mutant flies are starvation sensitive, reflecting FOXO-dependent increases in lipolysis that deplete triglyceride stores; reducing HDAC4 expression restored lipid accumulation. Our results reveal a hormone-regulated pathway that functions in parallel with the nutrient-sensing SIRT1 pathway to maintain energy balance. https://www.delphistem.com/welcome daily 0.75 2024-02-08 https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/832ec7f3-f52f-4ed5-b4e7-a3e2bdd4a92b/Picture1234.png https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/ba0ccc67-90fd-4ba4-9d6c-3d8c6ccf5a8b/kevin-schmid-QpKvh4KuaSE-unsplash.jpg https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1706294649374-3XHWM2Y803KB0NSGE4SZ/image-asset.jpeg https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/7b5d9b81-8eba-4aa8-856b-57810a9fc5a4/pexels-antoni-shkraba-production-8791260.jpg https://www.delphistem.com/faqs daily 0.75 2024-10-31 https://www.delphistem.com/subscriptions daily 0.75 2024-05-22 https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/ba0ccc67-90fd-4ba4-9d6c-3d8c6ccf5a8b/kevin-schmid-QpKvh4KuaSE-unsplash.jpg https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1705515514547-3DKHIR57PSPGAY4R0ZS8/image-asset.jpeg https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/7b5d9b81-8eba-4aa8-856b-57810a9fc5a4/pexels-antoni-shkraba-production-8791260.jpg https://www.delphistem.com/instructions daily 0.75 2024-02-08 https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/a64d559c-e582-4325-99d0-56f8e2e2973c/IMG_8159.jpg https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/4cfaeb97-d12b-4a16-bc9b-e5f1cc1f45d1/IMG_8153.jpg https://www.delphistem.com/terms-conditions daily 0.75 2024-02-16 https://www.delphistem.com/privacy daily 0.75 2024-02-20 https://www.delphistem.com/benefits daily 0.75 2024-02-26 https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1708978782371-BN7Z201UKIN05SMKISZI/image-asset.jpeg https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1708978899954-0KPR6PC5VWV3QD004YJ2/image-asset.jpeg https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/a95bead4-d289-4e53-8576-b7ebb818b1f0/Picture19.png https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1708979041666-ER75BOU69I6MG6AAY95J/image-asset.jpeg https://www.delphistem.com/the-science daily 0.75 2026-01-16 https://www.delphistem.com/why-now daily 0.75 2024-02-27 https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1709049912686-AE59KH4VAN4XUMFI6ESK/IMG_9552.jpg Why now? Cell: Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors, co-authored by Kazutoshi Takahashi and Shinya Yamanaka https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1712693424361-96OGSOCQX5J1YCQ0O8J7/IMG_2409.jpg Why now? Time Magazine: Why Are So Many Young People Getting Cancer? It's complicated. https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1709049503627-8LD4EV7Q0NDGI09X4TT7/IMG_9041.jpg Why now? CNN: Global cancer cases will jump 77% by 2050, WHO report estimates https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1709049866410-HH4003OYWLVEQF962QFY/IMG_9549.jpg Why now? RegMedNet: World-first transplant of iPSC-derived epithelial cell sheet. Osaka University scientists have transplanted a sheet of corneal epithelial cells derived from iPSCs in a world-first. The patient was treated for corneal epithelial stem cell exhaustion. https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1709049441847-0C8MWZRI5CMQ9S58MFK5/IMG_9045.jpg Why now? FT: The unexplained rise of cancer among millennials https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1709049885463-BKJXEHTN9WG2E27KVZT8/IMG_9548.jpg Why now? diaTribe Learn: Vertex Releases New Data on Potential Cure for Type 1 Diabetes. For many years, a cure for type 1 diabetes has only been a pipe dream for the millions of people living with type 1 diabetes. New data from Vertex Pharmaceuticals on the first people to receive a revolutionary cell therapy for type 1 suggests a significant step toward a cure. A third person with type 1 diabetes has achieved insulin independence after treatment with VX-880, a novel stem cell-derived beta cell therapy developed by Vertex Pharmaceuticals. https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1709050491010-NW191KNVP63DOJU17CBD/IMG_7350%2B3.jpg Why now? CNN: Cancer incidence rising among adults under 50, new report says, leaving doctors searching for answers https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/1709051415383-VRI0HHGQAA6CY6R4S9XW/IMG_A583C0421876-1.jpg Why now? There are currently 35 FDA-approved cellular and gene therapy products (45% increase from 2023) https://www.delphistem.com/what-diseases-could-stem-cells-be-used-for daily 0.75 2024-02-22 https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/23063aa8-7b64-4f40-8c22-703ee3e0daa0/IMG_A583C0421876-1.jpg https://www.delphistem.com/employers daily 0.75 2024-02-27 https://images.squarespace-cdn.com/content/v1/60db32f5a5b0d87cd91a9fc2/aa3a36d7-61c0-4813-baa3-6a217f1a184e/image-asset.png https://www.delphistem.com/how-it-works-1 daily 0.75 2024-02-27 https://www.delphistem.com/ourstory daily 0.75 2025-05-21 https://www.delphistem.com/home-lp daily 0.75 2024-03-28 https://www.delphistem.com/thank-you daily 0.75 2024-04-10 https://www.delphistem.com/hello-1 daily 0.75 2025-05-20 https://www.delphistem.com/hello-2 daily 0.75 2025-05-20